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Modes of replication 2
...
L
...
Leading strand is covalently linked to parental
template for the lagging strand (if double stranded)
2
...
Rolling circle continues unabated forming
concatemers (either as ds or ss products)
4
...
DNA can only be nicked to start the process if it is
supercoiled

Some critical aspects of rolling circle replication
1
...
Prior to precursor synthesis, the linear branch has a
5’ terminus (“A” protein must have acted there)
3
...
Circular template for leading strand synthesis never
leaves the circular part of the molecule
5
...
This is problematic because
of all of the origins of replication that are necessary;
this requires considerable regulation about when/where
replication will begin (we will deal with this aspect a bit
later)

This table is less than
10 years old and look
at the paucity of DNA
polymerases as
compared to Table
8
...
8
...
8
...
L
...
8
...
8
...
8
...
coli
Single replicator in E

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