Search for notes by fellow students, in your own course and all over the country.
Browse our notes for titles which look like what you need, you can preview any of the notes via a sample of the contents. After you're happy these are the notes you're after simply pop them into your shopping cart.
Title: Mechanisms of Heart Rate Regulation
Description: This is a lecture that is part of the St. Georges University Biomedical Science course in the Human Cardiovascular and Respiratory Pharmacology module.
Description: This is a lecture that is part of the St. Georges University Biomedical Science course in the Human Cardiovascular and Respiratory Pharmacology module.
Document Preview
Extracts from the notes are below, to see the PDF you'll receive please use the links above
Importance of Heart Rate
HR is a predictor of CVD mortality - acute/chronic disease
>70bpm considered to show increased risk
Fast HR linked to atherosclerosis/coronary artery plaque disruption
Determinant of myocardial O2 consumption
(Increased HR = Increased O2 consumption)
Determinant of coronary circulation perfusion time
Only occurs during diastole (Increase HR = Decrease in Cardiac Perfusion)
Low HR leads to decreased O2 demands
Lowering HR is a target for treating post-MI, angina, Heart failure, etc
...
g
...
Several inward currents, If
and the L- and T-type Ca2+-channels drive the depolarisation of the pacemaker cell, while
potassium currents are involved in repolarization
...
Adrenergic stimulation results in an increased heart frequency due to a faster pacemaker
rate
...
In addition the HCN channels have also a cAMP-binding
domain
...
2/1
...
1/3
...
Title: Mechanisms of Heart Rate Regulation
Description: This is a lecture that is part of the St. Georges University Biomedical Science course in the Human Cardiovascular and Respiratory Pharmacology module.
Description: This is a lecture that is part of the St. Georges University Biomedical Science course in the Human Cardiovascular and Respiratory Pharmacology module.