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Title: Potential anti-hypertensive targets in Vascular Smooth Muscle
Description: This is a lecture that is part of the St. Georges University Biomedical Science course in the Human Cardiovascular and Respiratory Pharmacology module.
Description: This is a lecture that is part of the St. Georges University Biomedical Science course in the Human Cardiovascular and Respiratory Pharmacology module.
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Rational for need of new anti-hypersensitive targets:
Increased risk of stroke, HF and Coronary artery disease
29% of global deaths = CVD
2008: CVD = 50,000 premature deaths
= £30 billion financial burden
Existing anti-hypertensive targets
Inhibition of VDCCs
Diuretics
e
...
Furozimide
Decrease BP leads to Increase HR which could increase ischaemia and HF due to
decrease diastole time and coronary perfusion
Angiotensin converting enzyme inhibitors (ACEi)
e
...
Enalapril
Angiotensin Receptor blockers
e
...
Zanostartin
VDCC -->
SERCA - decease Ca2+ intracellular
conc
...
1-Kv7
...
g
...
3 and 1
...
Endothelin converting enzymes - turns endothelin into active peptides
ETA and ETB receptors
...
Title: Potential anti-hypertensive targets in Vascular Smooth Muscle
Description: This is a lecture that is part of the St. Georges University Biomedical Science course in the Human Cardiovascular and Respiratory Pharmacology module.
Description: This is a lecture that is part of the St. Georges University Biomedical Science course in the Human Cardiovascular and Respiratory Pharmacology module.