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Title: V. Mechanisms of Repair
Description: BIOCHEMISTRY (2nd year) This covers mechanisms of repair of DNA damage, broken into three parts Part A covers repair of DNA damage (mismatch repair) caused during DNA replication Part B covers repair of damage caused by UV damage (excision repair) and Part C covers repair as a result of chemical modification (base excision repair and nucleotide excision repair) related to MCB2021F This is a biochemistry course taught at UCT follows the textbook - Biochemistry, Garrett & Grisham
Description: BIOCHEMISTRY (2nd year) This covers mechanisms of repair of DNA damage, broken into three parts Part A covers repair of DNA damage (mismatch repair) caused during DNA replication Part B covers repair of damage caused by UV damage (excision repair) and Part C covers repair as a result of chemical modification (base excision repair and nucleotide excision repair) related to MCB2021F This is a biochemistry course taught at UCT follows the textbook - Biochemistry, Garrett & Grisham
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V
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DNA replication – Mismatch repair
1
...
coli
When DNA is replicated, the newly synthesised strand must still undergo
methylation
...
B
...
Chemical modification – excision repair
1
...
and Grisham, C
...
(2010)
...
4th
...
892
...
Nucleotide excision repair
This method of repair recognises and then repairs larger regions of DNA damage
(compared to base excision repair)
The sugar phosphate backbone is cut on either side of the DNA damage or lesion
and this region is removed
...
The gap is then filled by DNA polymerase; DNA polymerase I in prokaryotes and
DNA polymerase δ or ε in eukaryotes
...
Title: V. Mechanisms of Repair
Description: BIOCHEMISTRY (2nd year) This covers mechanisms of repair of DNA damage, broken into three parts Part A covers repair of DNA damage (mismatch repair) caused during DNA replication Part B covers repair of damage caused by UV damage (excision repair) and Part C covers repair as a result of chemical modification (base excision repair and nucleotide excision repair) related to MCB2021F This is a biochemistry course taught at UCT follows the textbook - Biochemistry, Garrett & Grisham
Description: BIOCHEMISTRY (2nd year) This covers mechanisms of repair of DNA damage, broken into three parts Part A covers repair of DNA damage (mismatch repair) caused during DNA replication Part B covers repair of damage caused by UV damage (excision repair) and Part C covers repair as a result of chemical modification (base excision repair and nucleotide excision repair) related to MCB2021F This is a biochemistry course taught at UCT follows the textbook - Biochemistry, Garrett & Grisham