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Title: Cells and Life Forces
Description: Stage 1's Medicinal Chem course at Newcastle University. The key info are extracted from the original Powerpoint copy I received in 2017. Part 1 of 6

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Stage 1 Medicinal Chemistry – Section 1 of 6

Keywords
Prokaryote – Unicellular cells that form colonies or filaments
Cell wall – network of carbohydrates and amino acids
Plasma membrane – layer of phospholipids
Cytoplasm – intracellular fluid
Ribosomes – produces proteins
Golgi apparatus – forms proteins
Lysosomes – collects dead cells and defends cells

Flashcard Questions
What is the plasma membrane surrounded by?
Peptidoglycan layer
What is the peptidoglycan layer composed of?
Polysaccharides
polypeptides
What does is the function of a cell wall in bacteria?
Protects it from internal pressure
What does penicillin do?
Inhibits cell wall synthesis
Prevents colonisation of bacteria
What vitamin does bacteria produce?
K2
What forms micelles?
Salts of fatty acids

Written by AnonymousArmy21

Stage 1 Medicinal Chemistry – Section 1 of 6
What determines structure of biomolecules?
Strong bonds
If the PH is greater than the Pka between an amine and acid, which is ionic?
The acid is ionic
What happens when the PH = Pka?
A mixture of neutral and ionised compounds exist
How do dipoles come to be?
Due to differences in electronegativity
What types of molecules are involved in dispersion forces?
Temporary dipoles
Which type of molecules occasionally have even electron distribution?
Non polar molecules- this leads to no interaction
Uneven electron distribution will form temporary dipoles
What happens to a hydrogen bond when interaction is at a greater length?
They become dipole-dipole interactions, which are much stronger
What are hydrophobic interactions based on?
Entropy
What type of molecules do hydrophobic interactions involve?
Non polar molecules
Give 2 molecules that covalent bonds occur in
DNA
Polypeptides
What are ionic and hydrogen bonds in terms of biological systems?
Interaction between enzymes and small molecules

Written by AnonymousArmy21

Stage 1 Medicinal Chemistry – Section 1 of 6
Which 2 compounds does water solvate?
Ions
Polar molecules
What does weak interactions between molecules aid?
Protein folding

What weakens hydrogen, ionic and dipole dipole bonds?
Water

Written by AnonymousArmy21


Title: Cells and Life Forces
Description: Stage 1's Medicinal Chem course at Newcastle University. The key info are extracted from the original Powerpoint copy I received in 2017. Part 1 of 6