Search for notes by fellow students, in your own course and all over the country.
Browse our notes for titles which look like what you need, you can preview any of the notes via a sample of the contents. After you're happy these are the notes you're after simply pop them into your shopping cart.
Title: Drug Dissolution
Description: Level 1/2 pharmaceutics Drug dissolution notes, explaining variables and techniques for drug analysis
Description: Level 1/2 pharmaceutics Drug dissolution notes, explaining variables and techniques for drug analysis
Document Preview
Extracts from the notes are below, to see the PDF you'll receive please use the links above
Drug Dissolution Notes
1
...
• dC/dt = k ∙ A(CS – CB)
• dC/dt – rate of drug dissolution
• k – dissolution of rate constant = D/h
• D – diffusion coefficient
• h – thickness of diffusion layer
• A – surface area of the drug
• CS – saturation solubility of the drug
• CB – concentration of the drug in the bulk solution
• Sink condition occurs when CB is equal to 10% to 20% of CS
2
...
g
...
g
...
= ↑ rate)
• Composition – whether the solvent is a pure compound (such as distilled water) or a mixed
compound (i
...
water and alcohol) can affect the rate of dissolution depending on whether or
not the drug interacts with the solvent differently; perhaps the two will react together?
• Viscosity – a higher viscosity impedes dissolution (solvent molecules surrounding solute
molecules will take longer)
Concentration gradient – the larger the concentration (CB) the smaller the rate; can be shown using
equation
3
...
In the process of dissolution, the particles of the solute diffuse into
an area of lower concentration; in other words, they diffuse into the solute around them
...
4
...
Differentiate between sink, non-sink, and essential sink conditions during dissolution
tests
• Sink condition: the condition in which equilibrium is reached between solute going out and in
(can be explained using the sink analogy; if you unplug a sink and turn on the tap, when the
amount of water entering and leaving the sink are the same sink condition has been reached)
• Non-sink conditions: equilibrium is shifted either way
• Essential sink conditions: occur when CB is equal to 10% of CS
b
...
Present and interpret data from dissolution experiments
Basically just understand graphs or equations having to do with dissolution
Title: Drug Dissolution
Description: Level 1/2 pharmaceutics Drug dissolution notes, explaining variables and techniques for drug analysis
Description: Level 1/2 pharmaceutics Drug dissolution notes, explaining variables and techniques for drug analysis