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Title: Role of t cell in malignancy
Description: One page contains role of t cell in killing cancer cells in a short diagram other page contains information regarding how cancer cells effect t cells
Description: One page contains role of t cell in killing cancer cells in a short diagram other page contains information regarding how cancer cells effect t cells
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Tumour cells
Consumed by tumour
cells and infiltrating
immunosuppressive
cells
Cytokines and
chemokines
Immunosuppressive metabolites
• Lactate
• Hypoxia
Kynurenine
PGE2
Adenosine
Protumourigenic
Immunostimulatory nutrients
immune cells :
• Glucose
• APC
• Glutamine
Trey cell
Arginine
MDSC
Tryptophan
M2 –like
• leucine
macrophage
Immunosuppressive
cytokines :
• TGFB
IL-6
IL-10
VEGF
Dysfunctional
antitumour T cells
Title: Role of t cell in malignancy
Description: One page contains role of t cell in killing cancer cells in a short diagram other page contains information regarding how cancer cells effect t cells
Description: One page contains role of t cell in killing cancer cells in a short diagram other page contains information regarding how cancer cells effect t cells