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Title: Laboratory Diagnosis of Babesiosis
Description: This is a brief overview of the biology and laboratory diagnosis for Babesia spp, the etiologic agnt for Babesiosis
Description: This is a brief overview of the biology and laboratory diagnosis for Babesia spp, the etiologic agnt for Babesiosis
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BLOOD AND TISSUE PROTOZOA: BABESIOSIS
•
Also caused by apicomplexan protozoa found nearly worldwide
•
infects RBCs
•
primarily a disease of temperate regions
•
found in a variety of animal species that serve as reservoirs
•
Ticks – primary (also the definitive host)
•
May also be acquired via (less common)
o Blood transfusion
o Transplacental/congenital
2
...
Microti
B
...
Divergens – most
common
B
...
DISEASE
•
Immunocompetent individuals:
o Malarial-like; except no periodicity
o Chronic subclinical infection may also occur
•
asymptomatic infections in immunocompetent patients generally
do not require treatment
•
Can be fatal in HIV (+) and splenectomized patients
•
generally treated using
o atovaquone plus azithromycin or
o clindamycin plus quinine
4
...
Falciparum
•
Usually multiple → usually forms tetrads called “Maltese cross”
•
Extracellular forms may be seen in heavy infections
•
Also have oval, round, spindled, “racket forms” simultaneously
•
>4 trophozoites per RBC, no Maurer’s cleft
•
No hemozoin pigments
•
•
•
Other Forms of testing: (1) NAAT; (2) Serologic tests e
...
IFA’s
Serologic tests for malaria are negative in Babesiosis
Patents with malaria may cross-react in Babesia serologies
References: Henry's Clinical Diagnosis and Management by laboratory
Methods 24th edition
Title: Laboratory Diagnosis of Babesiosis
Description: This is a brief overview of the biology and laboratory diagnosis for Babesia spp, the etiologic agnt for Babesiosis
Description: This is a brief overview of the biology and laboratory diagnosis for Babesia spp, the etiologic agnt for Babesiosis