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Title: Enzymes in diagnosis
Description: These are very good notes on enzymes for anyone pursuing a Bachelor's Degree in Biochemistry or Human Biology. I use these notes to lecture Biochemistry for Medical Students at the University of Zambia
Description: These are very good notes on enzymes for anyone pursuing a Bachelor's Degree in Biochemistry or Human Biology. I use these notes to lecture Biochemistry for Medical Students at the University of Zambia
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ENZYMES IN DIAGNOSIS
Ms Lulembo
• Some enzymes or isozymes are expressed in
response to specific physiologic or
pathophysiologic changes
...
• Certain enzymes, proenzymes, and their substrates
are present at all times in the circulation of normal
individuals and perform a physiologic function in the
blood
• these are functional plasma enzymes and include
lipoprotein lipase, pseudocholinesterase, and the
proenzymes of blood coagulation and blood clot
dissolution
...
These apparently nonfunctional plasma
enzymes arise from the routine normal
destruction of erythrocytes, leukocytes, and
other cells
• Tissue damage or necrosis
resulting from injury or disease is generally
accompanied by increases in the levels of
several nonfunctional
plasma enzymes
...
• The subunits can combine as shown below to
yield catalytically active isozymes of
L-lactate dehydrogenase:
• Since heart expresses the H subunit almost
exclusively, isozyme I1 predominates in this tissue
...
• After a myocardial infarction or in liver disease,
the damaged tissues release characteristic lactate
dehydrogenase isoforms into the blood
• A –heart condition
• B- normal person
• C- liver condition
Assignment/Research
• 1
...
• 2
...
Explain how enzymes are used in diagnosis
of genetic disease
Title: Enzymes in diagnosis
Description: These are very good notes on enzymes for anyone pursuing a Bachelor's Degree in Biochemistry or Human Biology. I use these notes to lecture Biochemistry for Medical Students at the University of Zambia
Description: These are very good notes on enzymes for anyone pursuing a Bachelor's Degree in Biochemistry or Human Biology. I use these notes to lecture Biochemistry for Medical Students at the University of Zambia