Search for notes by fellow students, in your own course and all over the country.
Browse our notes for titles which look like what you need, you can preview any of the notes via a sample of the contents. After you're happy these are the notes you're after simply pop them into your shopping cart.
Document Preview
Extracts from the notes are below, to see the PDF you'll receive please use the links above
GOUT
ARTICULAR CRYSTAL DEPOSITION IS ASSOCIATED WITH
MONOSODIUM URATE-GOUT
CALCIUM PYROPHOSPHATE
BASIC CALCIUM PHOSPHATE
“DISEASE OF KINGS”
EPIDEMIOLOGY OF GOUT
USUALLY ADULT MEN
5% FEMALE-RARE IN CHILDREN AND AN WOMAN
DURING REPRODUCTVE YRS
POSITIVE CORELATION-PROTEIN INTAKE ,MEAN
WT,ALCOHOL CONSUMPTION,SOCIAL
CLASS,INTELLIGNCE
GOUT
CLASSIFICATION OF GOUT
Primary gout(90%)
Diet
unknown Enzyme defect
Known enzyme defect(HGPRT)
Reduced excretion of uric acid
Gout classi……
SECONDARY GOUT(10%)
A) OVER PRODUCTION LESS EXCRETION
(LEUKEMIA AND AGGRESSIVE
NEOPLASM)
B) INBORN ERROR OF METABOLISM(HGPRT)
C) REDUCED EXCRETION-CHR RENAL FAILURE
PATHOGENESIS
OF GOUT
Purine metabolism
I ) de novo pathway
II) Salvage pathway
HYPERURICEMIA
Renal transport system
GFR
Reabsorption
Secretion
Post secretory reabsorption
Hypoxanthine guanine
phospho ribosyl transferase
(HGPRT)
CONTRIBUTING FACTOR FOR GOUT
Age > 20-30
Genetic predoposition-X linked multifactorial runs
in family
Heavy alcohol
Obesity
Drugs-thiazine
Lead toxicity
PATHOGENESIS……
...
ACUTE ARTHRITIS
2
...
TOPHI AT MULTI SITES
4
...
ASYMTOMATIC HYPERRICEMIA
2
...
INTERCRITICAL GOUT
4
...
TUBERCULAR ARTHRITIS
HAEMATOGENOUS SPREAD
SECONDARY TO PULMONARY TUBERCULOSIS