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More Androgens you have - faster the cancer will grow
Can give chemical castration or physical castration
PSA = Prostate Speciļ¬c Antigen
Marker for prostate cancer - not necessarily indicative of cancer
BPH (Benign Prostatic Hyperplasia) can also express it
CRPC - Castrate Resistant Prostate Cancer
Cancer still grows despite castration
Adrenals produce testosterone
Adrenal glands give you steroids to give you oestrogen post-menopausal as ovaries have
atrophied
Tamoxifen - given to pre-menopausal women
Can't give them aromatase inhibitors as ovaries would be stimulated by HPG axis to
produce more oestrogen! (hence given to post-menopausal only)
Can remove ovaries (irreversible)
LH suppression (reversible)
Micrometastasis
Hormone treatment can starve these
Usually done as even though you may have removed the main cancer - could be
micrometastasis
Duration of drug therapy is important
Longer you are on Tamoxifen/Aromatase Inhibitors - less risk of reoccurrence
mTOR - Mammalian Target of Rapamycin
mTOR inhibitors can make cancer dependant on hormones (again) which can then be
blocked