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Protection against your own tumour but not other tumours from other mice
Immunoediting - Immune system against tumour cells
Danger signals - allows immune system to see tumours
γδ T cells, NK cells, NKT cells - linking innate to adaptive seem to be the first cells to
respond to tumour
DCs take in tumour Ags & go to lymph nodes & makes memory cells
Much quicker & better at responding to cancer
TAA = Tumour Associated Antigens
Immune system could be selecting out tumour cells that can avoid destruction by immune
system
Mutations allowing cancer progression:
Production of anti-inflammatory action
Decreased IFN-γ response --> decreased MHC-I production
Block NK cells
Etc