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Title: Antibodies and B Cells
Description: 2nd Year Biomedical Science Tertiary Education. Immunology module notes on Antibodies and B Cells. All images in my notes are credited to google for easier references.
Description: 2nd Year Biomedical Science Tertiary Education. Immunology module notes on Antibodies and B Cells. All images in my notes are credited to google for easier references.
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Antibody and B cells [ PROBLEM 3 ]
HMI (Adaptive)
Antibody or Immunoglobulin (lg)
Disulphide bonds
Affinity
Hinge
Strength of a single antibody - antigen interaction
...
Proteins, carbohydrates, lipids and nucleic acids can all be
recognized by antibodies
...
Little
antibodies is secreted
...
B cell : acts as a B cell receptor (BCR)
...
g tears, saliva,
breast milk & intestine)
- J chain is required for transportation to mucosal surface as IgA is a dimer
- Protects mucosal surface by neutralizing pathogens & activating phagocytes
IgM is secreted as pentamer (Pentameric)
- *There will only be 1 monomer on the B cell but during secretion the other 4 will be out
thus (+1) 5 = pentamer
- 1st antibody expressed on B cell
- High antigen binding capacity ; high binding valency
- Low binding affinity to antigen
- Effective at complement activation
IgE :
- Least abundant antibody in the blood
- Binds to mast cell surface
- Allergen binding to IgE activates mast cells
- Protects us from parasites (e
...
g nasal,
tonsil)
- Activates basophils & mast cells to induce inflammation
and antimicrobial response
IgG :
- Most abundant antibody (70-75% of total antibodies) in blood
& intestine
- High binding affinity to antigen
- Transferred from mother to fetus across placenta
- Activate complement
- Activate phagocytes
- Mediate natural killer cells
- Binds to mast cell surface
- Allergen binding to IgE activates mast cells
- Protects us from parasites (e
...
Neutralization
- Directly neutralize or block toxins or
pathogens
...
NO
other cells or molecules are required for this
process
- Activate complement system and NK
cells, phagocytes & granulocytes to
promote target destructions
2
...
3
...
Antibody
binding to cell surface antigen can
promote ADCC through NK cells
4
...
Inflammation
- Binding of mast cells and basophil at
Fc region of IgE = release histamine to
trigger inflammatory process
There are many gene segments for V,D, J
In one B cell, one segment from each V,D, J is chosen to make 1 unique antibody
Mature B cells produce surface IgM and IgD
...
Mature B cell
Mature B cell activated (antigen bound)
Plasma cell + Memory cell
Clonal Selection :
Antigen will activate specific clone of B cells
...
Activated B cells will undergo affinity maturation (higher antigen binding affinity) & class
switching (IgE, IgA, IgG)
Immunology Page 2
Title: Antibodies and B Cells
Description: 2nd Year Biomedical Science Tertiary Education. Immunology module notes on Antibodies and B Cells. All images in my notes are credited to google for easier references.
Description: 2nd Year Biomedical Science Tertiary Education. Immunology module notes on Antibodies and B Cells. All images in my notes are credited to google for easier references.