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Darwinian Medicine/Evolutionary Medicine
Darwinian Medicine
Applying evolutionary theory to health and disease
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Darwinian Medicine looks @ WHY we get sick instead of HOW we get sick
Thalidomide and flipper babies
o Drug used to treat morning sickness
o Disconnect between treating morning sickness and understanding why it exists
...
Recent research has supported this notion but not to the extent that being flooded with
parasites in childhood is widely beneficial
...
o Immune system may not develop properly without exposure to these pathogens
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o Recent innovations such as sanitation departments, and clean running water has
reduced exposure to deadly pathogens such as cholera, but has also reduced our
exposure to old friends
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w/ allergies
The more gut microbial diversity you have the less likely you will suffer from
an allergic disease
Tests have shown that parents that stick the pacifier in their mouths after it falls on the floor
before giving it back to their baby have less allergic disease than the parents that sanitize the
pacifier and then give it back clean
The babies w/ the parents that suck the pacifier before giving it back to them
are acquiring the germs that their parents have which aren’t harmful but help
the immune system grow from what the parents pass on
Allergies
o In urban centers, 9
...
2 percent in
rural communities
Crohn’s Disease
o Characterized by various genetic abnormalities that lead to overly aggressive T-cell
responses to a subset of commensal enteric bacteria
...
Win within the body (group) but the group loses as a result
...
after the first round of chemo the weak cells were killed now the little trail of stronger cells
were left behind which will now multiply with time making a bigger and stronger colony
o Endostatin was used to target and inhibit the angiogenesis factors that trigger the
growth of new blood vessels which they feed off of and it was successful in bringing
cancer cell #’s down -> reducing their response to selection -> cutting off their food