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Title: Male Reproductive System
Description: University notes on the male reproductive system.
Description: University notes on the male reproductive system.
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Functions of the Male
Reproductive System
• Spermatogenesis
• Delivery of spermatozoa to female
• Production of male sex hormones
– Development of secondary male characteristics
– Development of sex drive (libido)
Reproductive Tract of Boar
• Large volume of ejaculate
produced by boar
______________
• Coitus is protracted in this
species (up to 30 minutes)
• Spiralling of end of penis
• End of penis believed to
enter uterus
Reproductive Tract of Bull
• ____ penis
• Spiralled at end
• Sigmoid flexure
1
• Prepuce protects non erect penis
Semen Collection Bull
Cryptorchidism
Anatomy of Testis
• Failure of Testes to Descend during prenatal life
– ____ of infants and ________ % of premature infants
– ↑ risk of testicular cancer
– __________ needs not met
– Endocrine function not impaired
•
Normal sexual drive but sterile
• ↑ ________ ___________
– temporary sterility of long distance runners, cyclists –
Don’t work with laptop on your knee!
• Testis- divided into 200-400 compartments by fibrous connective
tissue- lobules
• Each lobule contains 1-4 highly convoluted seminiferous tubules in
which sperm are formed
• Sperm prod
...
___________ cells
2
...
___________ cells
• Lie between _________ tubules
• Testosterone
2
Spermatozoa
Spermatogenesis
•
• Head
From Spermatogonia (2n) to mature Spermatozoa (n)
– Man ~____________
– Acrosome - Fertilisation
– Bull ~___________
– Haploid Nucleus - Condensed
DNA
– Ram ~____________
• Different stages of differentiation in each seminiferous tubule
• Midpiece
– ______________
• Spermatozoa may be present in some tubules and
predominantly spermatids or primary spermatocytes in others
– Mitochondria- ___________
Production (ATP for
locomotion)
• Each day ~_________ million sperm complete spermatogenesis
• Tail: Flagellum
– __________ Structure/Movement
Sertoli Cells -
Sertoli Cells - Functio ns
Functions
4
...
_________
–
Of the Seminiferous Tubule Cells –
– Androgen Binding Protein (ABP)
Once fully differentiated
the Sertoli cell is unable
to proliferate
– Inhibin
– Activin
Inner Tubule - Avascular
•
5
...
____________
Cytoplasmic Droplets from
Spermatids
–
Damaged Germ Cells
–
3
...
____________
•
– ⇑ growth of laryngeal cartilage- Adam’s apple
Stimulates spermatogenesis and
spermiogenesis
2
...
3 mg/day
– Improved Athletic Performance
– ⇑ BMI, ⇑ RBC Density, ⇑ Oxygen Utilizatio n
• In genetically susceptible men causes ‘Male pattern baldness’
Regulation of Testosterone
---
Hormonal Control of the Testes
• At __________
–
Hypothalamus ↑
secretion of GnRH –
Secretion
Why ???
---
__________
GnRH
• ______________
(puberty)
– Stimulates the
anterior pituitary
Anterior Pituitary
•
LH
FSH
•
FSH
LH
Activin/Inhibin
_______ Cells
_______ Cells
Sertoli Cells - Hormonal Functions
•
•
FSH stimulates Sertoli cells to express androgen binding protein
_______________ (ABP)
–
–
–
•
_________________
–
–
•
Secreted post puberty
Inhibits FSH
______________
–
–
•
Transports testosterone
Maintains Testosterone levels in seminiferous tubule
•
Essential for spermatogenesis
Facilitates sperm maturation
Secreted post puberty
Stimulates FSH
•
Modulate Spermatogenesis Via FSH
Convert Androgens to Estrogens
– Aromatase from sertoli cells convert testosterone to estrone & DHT
to direct spermatogenesis
–
Hormonal Modulation of Tubular Function
Pathways to pregnancy &
parturition
...
Senger
Anatomy of the Penis
Physiology of Penile Erec tion
Male Accessory Glands
1
...
__________ (x1) - Secretes about 30% of the Seminal Fluid
Reproductive function is to deposit semen in
female reproductive tract during intercourse
Erection
– Slightly acidic (PH ~6
...
______________ Glands (Cowper) (x2)
– Mucous, Alkaline Secretion
– Lubrication
– Transport and Neutralize the Acidic pH of Urethra
Ejaculation
Semen contains
1
...
______________ (99%)
• Reflex sensory nerves to spinal cord- impulses to:
– _________ monosaccharide used by mitochondria of sperm for
energy production
– Smooth muscle of ____________ and Vas deferens
• contract release sperm
– Buffer- neutralises acidic secretions of female reproductive tract
– Smooth muscle in walls of sex accessory glands
– ________ may stimulate uterine contractions- assist with movement
of sperm up female tract
• secretions into vas ______________ and urethra
– Smooth muscle contraction of urethra release of semen during
ejaculation
– Some lymphocytes (may be method of HIV viral spread)
Sperm Quality Tests
Volume & normal sperm concentration
•
Concentration
•
<20 million/ml = low sperm count
–
Ram
Bull
Boar
Stallion
Man
Man average ___________ million sperm/ml semen
– ↓ by 1-2% per year over the last 2 decades
5
Volume of ejaculate (ml)
1-2
5-8
200-250
50-100
2-4
•
Motility
2000-3000
800-2000
200-300
50-300
60
•
Morphology
________________________
Concentration of
spermatozoa
(10 6/ml)
__________
•
Number of spermatozoa
per ejaculate (x10 9)
1
...
5
5-15
30-60
5-15
120-240 x10 6
PH
–
•
tract???
_____________________
How long can sperm live in the female reproductive
6
Title: Male Reproductive System
Description: University notes on the male reproductive system.
Description: University notes on the male reproductive system.