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•
CAPSULE NO & THEIR APPROXIMATE CAPACITY IN mg & ml
000 - 950 - 1
...
95
0
- 450 - 0
...
50
2
- 250 - 0
...
30
4
- 150 - 0
...
13
PROPORTIONS REQUIRED FOR A PRIMARY EMULSION
(oil:water:gum)
Fixed oils :- 4:2:1
Volatile oils:- 2:2:1
Mineral oils:- 3:2:1
Oleoresins:- 1:2:1
CODE: LPSO ( apply this for tweens & spans)
for eg
...
11
11 - 15
good
1
...
18
16 - 20
fair
1
...
25
21 - 25
passable
1
...
34
26 - 31
poor
1
...
45
32 - 37
very poor
1
...
59
very very poor
> 1
...
Used for Buffered and Unbuffered aqueous solution
...
Buffered aqueous solution below pH 7
...
Used for dry powder and oily solution
...
Not for parenteral, for tablet,liquid oral and externals
...
organic-chemistry
...
htm?http://www
...
org/namedreactions/ or
http://www
...
de/chemistry/name_reactions
...
tomchemie
...
h
...
pharmatestseries
...
increase substate level
4)Short actin Drug…
...
Dry heat sterilizatn,moist heat,aseptic fillin
10)D-glyceraldehyde configuration…S,R,RS
11)D-threose,D-erythrose,Lthreose related ques
12)erythrose and threose are???
...
Kolkata,jaipur,Bombay
15)preterm delivery vch drug use??
...
Apigenin,Umbeliferone
17)Vch of following obtaind frm marine????
...
Ans protamine sulphate
19) 8 hrs…40km/hr…60 km/hr…
...
ii
...
IR range,,i=ii>iii,i>ii>iii
27)NH gives peak at
...
29)Intracutaneous Max vol…
...
01,0
...
2,1
30)BCCI memb
31)Fecl3+catechol colour…
...
Blood,lung,
34)Vch tissue has slowest equilibrium drug in blood…brain,fat,muscle,liver
35)platelets obtained from?? Ans megakaryotes
36)h2o nd D2O attack…Elimination,SN2,SN1
37)Walden inversion…
...
7
...
micronization,spray
drying,any of above
41)emulsion measurement not by…
...
11…
...
triamterine
...
Allene,biphenyl
...
not chiral,restricted rotation
...
Bz
...
ans DX
51)20student height 120,10 student height 100…Avg height ans 105
52)Sania mirza…
...
teva,sanofi,Pfizer
...
fatima…
55)WOF used in tretmnt of diarrohea…erythromycin,domperidone,cisapride nd
one new drug
56)cycloaddition
...
antracene,naphthalene…
58)synthetic Ach better than natural Ach…
...
polystrene…
61)bond energy…
...
ionizdform,unionized form…
64)WOf is not sede efeect of phenothiazine???
65)WOFis not hepatotoxic??
...
tetracycline,macrolide
67)Inhibitr f 50 s …
...
Ethambutol
...
5 to 3,3 to 5,5 to 3 wth exonuclease,
77)SP angle…180
78)sesqueterpene havin isoprene unit,,,ans 3
79)In chewable tablet vch is usd?? Mannitol…
80Manitol used bz
...
2
...
3
...
4…
...
83)Condensed tannin…Ans proanthocyanidin
84)Not sterilized by moist heat…taflon,polystyrene,polyethylene
85)leucopenia…decrese size of WBC,increase size f WBC
86)Estrogen higher level vch toxicity produce??
...
Less,more
88)Father f pharmacognosy
...
90)Organic cmpd+UV…
...
UV,IR,Mass,Nmr
92)St phase in cellulose chromatography…silica gel,water without OH
...
95)WOF is wrong…aquacoat means enteric coatin
96)WOF is nt disacchrides…
...
steroid synthesis,fat synthesis,
98)feed back inhibitin…
99)composite family nd one source belong to…
...
75
102)Increse polarity
...
Urine formation,glucose formation,
105)Metabolite of hormone stored in…pancreas,adrenal medulla
...
cerebrum,cerebellu,
109)cardiac output/min calld……
...
112)Acute amoebic dysentery vch drud used
...
113)Flourouracil
...
115)NSAIDS induced GITproblem handled by…mesoprostol
116)Insulin ph 5
...
MCC,silica,both,none
119)Acetylene value……ans lower than alkene
120)free radical stability…
...
ans planar
122)str of twisted boat…
...
internal plane f symmetry
...
sulindac,sulphasalazine,aspirin
125)WOF is induced in allergy…IgE
126)WOF is participate in complement sym…IgG,IgM,IgE,IgA
127)Disinfectant fluid…
...
130)agaropectin made up f…
...
increse cl level
135)Stainin
...
S,SO2
138)IND full form
139)WOf is not product f dabur…
...
syrup coatin
141)Interfacial tensn measured by
...
MCC,lactose
144)Mg stearate added in vch step of wet granulation…durin granulation,aft
granulation
145)GC principle…adsorption,partition,both
146)Na salt f sachrin usd as…
...
20%,80% lyk ques
149)Arsenic test apparatus use??…nessler cylinder
150)Doctor without border smthin lyk ques
151)subsidy definition
...
less OH at 3rd
carbon,More OH at 3rd carbon,lessH at 3rd carbon,more H at 3rd carbon
153)In m-RNA nucleotides are joinee by…phosphodiester bonds,glycosidic
bond,hydrogen bond
154)Vd=X/C related ques,,ans 5 L
155)WOF is stron base…
...
1 N hcl…60,120,180,45
157)WOF used in efervesent tablet…citric acid+Na bicarbonate
...
159)Contact angle related ques
160)Draves test,,ans weting angle
161)Cafeeine gives
...
163)Rhem rhizome use…
...
adeneni nd guanine,adenine nd thiamine,cytosine nd
thiamine,
165)Topotecan…natural,synthetic,
166)H
...
Antihypertensive,
168)Daughter cells divided in…Prophase,Anaphase,telophase
169)Company acquire vch hospital???
...
PVA,PVP
173)antioxidant wth reducing Prop??
...
176)Increase lipase level indicate vch organ functn test…
177)USP apparatus 2…ans Paddle
...
ans vestibular disturbance
179)Podophylotoxin…lignan dvt…
...
Acetaminophen---NAC (N-acetyl-L-cysteine) dosage
2
...
Heparin---- protamine
4
...
Antidepressants
a
...
SSRI’s-----cycloheptadine
6
...
Beta antagonists----- glucagon and epinephrine
8
...
Cocaine---- BZD’s for seizuries; labetalol for hypertension; Neuroleptics for psychosis
...
Cyanide----amyl nitrite; sodium nitrite; sodium thio sulphate
11
...
Electrolytes
a
...
Potassium-------10%CaCl2 10%; NaHCO3(causes intracellular shift of pot);
glucose & Insulin (intracellular shift of pot
...
Iron------ deferoxamine (chelate iron)
14
...
Lead-------- Ca Disodium EDTA ; BAL (dimercaprol)
16
...
Opiates-----naloxone; nalmefene
18
...
Salicylates------activated charcoal
20
...
B)DiptheriaSchick test,elex test
C) T
...
See More
•
MICRO ORGANISMS USED AS BIOASSAYS FOR VITAMINS
ASSAY MICRO ORGANISM
-
VITAMIN
lactobacillus casei
biotin,folicacid,pyridoxal,riboflavine
l
...
leichmanii
calcium pantothenate,nicotinic
-
l
...
carlsberginsis •
pridoxine
Biological indicators
moist heat sterilisation (121 degre Centi ):
bacillus stearo thermophilus
dry heast sterilisation (160 degre centi) :
bacillus subtilis var niger
hydrogen peroxide and peracetic acid
:
bacillus stearo thermophilus
ethylene oxide , formaldehyde
:
bacillus subtilis var niger
ionising radiation
•
Tests and their uses
watson schwartz test - urobilinogen
schumms test - heme
carrprice test - vit A
gmelins test - bile pigments
gothlin test - scurvy
gofmann test - serum cholesterol
murexide test - uric acid
:
bacillus pumilis
reinsch test - heavy metals
gordons test - spinal fluid
biuret test - peptides
legals test- for estimation of acetone
ames test - carcinogenicity
•
side effects nd shortcuts
Short cuts for GPAT AND NIPER
Busulfan feature : ABCDEF
Alkylating agent
Bone marrow suppression
CML Indication
Dark skin(hyperpigmentation)
Endocrine insufficiency(adrenal)
Fibrosis
Drugs causing Torsades de Pointes:APACHE
Amiodarone
Procainamide
Arsenium
Cisapride
Haloperidol
Erythromycin
Morphine side effects :MORPHINE
Myosis
Out of it(sedation)
Respiratory depression
Pneumonia(aspiration)
Hypotension
Infrequency(constipation,urina
ry retention)
Nausea
Emesis
Aspirin side effects :ASPIRIN
Asthma
Salicylism
Peptic ulcer disease/phosphorylation-oxidat
ion uncoupling/platelet disaggregation
Intestinal blood loss
Reye's Syndrome
Idiosyncracy
Noise(tinnitus)
SSRIs side effects :SSRI
Seratonin syndrome
Stimulate CNS
Reproductive disfunction in male
Insomnia
Inhalation anesthetics : SHINE
Sevoflane
Halothane
Isoflurane
Nitrous oxide
Enflurane
Teratogenic drugs :"Win TERATogenic
Warfarin
Thalidomide
Epileptic drugs:Phenytoin,Valproate,Carb
amazepine
Retinoid
ACE inhibitor
Third element :Lithium
Gynaecomastia causing drugs:DISCOS
Digoxin
Isoniazid
Spironolactone
Cimetidine
Oestrogens
Stilboestrol
Methyldopa Side effects :METHYLDOPA
Mental retardation
Electrolyte imbalance
Tolerance
Headache/ Hepatotoxicity
psYcological upset
Lactation in female
Dry mouth
Oedema
Parkinsonism
Antirheumatic agents :CHAMP
Cyclophosphamide
Hydroxycloroquine and choloroquinine
Auranofin and other gold compounds
Methotrexate
Penicillamine
Phenytoin: adverse effects PHENYTOIN
P-450 interactions
Hirsutism
Enlarged gums
Nystagmus
Yellow-browning of skin
Teratogenicity
Osteomalacia
Interference with B12 metabolism (hence anemia)
Neuropathies: vertigo, ataxia, and headache
Sodium Valproate side effccts VALPROATE
Vomiting
Alopecia
Liver toxicity
Pancreatitis/ Pancytopenia
Retention of fats (weight gain)
Oedema (peripheral oedema)
Appetite increase
Tremor
Enzyme inducer (liver)
Amiodarone: action, side effects: 6 P's:
Prolongs action potential duration
Photosensitivity
Pigmentation of skin
Peripheral neuropathy
Pulmonary alveolitis and fibrosis
Peripheral conversion of T4 to T3 is inhibited -> hypothyroidism
Antiparkinson Drugs :SALAD
Selegiline
Anticholinenergics (trihexyphenidyl, benzhexol, ophenadrine)
L-Dopa + peripheral decarboxylase inhibitor (carbidopa, benserazide)
Amantadine
Dopamine postsynaptic receptor agonists (bromocriptine, lisuride, pergolide)
Therapeutic Index Formula TILE
TI = LD / ED
Anti epeleptic drugs Dr
...
Deoxy barbiturates
Barbiturates
Hydantoin
Aliphatic carb acids
Iminostilbenes
Succinimides
BZD's
Newer drugs
Phenyltriazines
Cyclic gaba analogues
Adverse effects of Tetracyclines-KAPIL DEV
Kidney toxicity
Antianabolic effect
Phototoxicity
Liver toxicity
Diabetes insipidus
CAPTOPRIL Side effects CAPTOPRIL
Cough Angioedema
Agranulocystosis
Proteinuria/ Potassium excess
Taste changes
Orthostatic hypotension
Pregnancy contraindication/ Pancreatitis/ Pressure drop (first dose hypertension)
Renal failure (and renal artery stenosis contraindication)/ Rash
Indomethacin inhibition
Leukopenia/Liver toxicity
Lithium: side effects LITH
Leukocytosis
Insipidus [diabetes insipidus, tied to polyuria]
Tremor/ Teratogenesis
Hypothyroidism
Myocardial Infarction(MI): signs and symptoms PULSE
Persistent chest pains
Upset stomach
Lightheadedness
Shortness of breath
Excessive sweating
MI: basic management (Shortcut:BOOMAR)
Bed rest
Oxygen
Opiate
Monitor
Anticoagulate
Reduce clot size
Treatment of Heart Failure: ABCDE
ACE inhibitors
Beta-blockers
Calcium channel blockers
Diuretics
Endothelin-converting enzyme inhibitors
Essential Amino acids
Methionine
Threonine
Leucine
Isoleucine
Tryptophan
Valine
Lysine
Phenyl alanine