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Title: Detailed protein notes
Description: Detailed protein study notes used for first year bachelor of Biomedical science at Queensland University of Technology. Basic foundation for anyone studying or wanting to study biology or medicine at university.
Description: Detailed protein study notes used for first year bachelor of Biomedical science at Queensland University of Technology. Basic foundation for anyone studying or wanting to study biology or medicine at university.
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182 Lecture 3 Proteins
Amino acid = monomers joined in a linear chain
...
R group is what determines the Amino Acid
...
Polypeptide Bonds
– Link amino acids together via condensation reactions
– Covalent bonds (Very strong)
Cysteine bonds
- Sulfhydryl group – SH group attached to R group
o 2SH groups attached to cysteines can interact to form a Disulphide bridge
under oxidizing conditions
...
- Are stable at high temperatures
Protein structure levels
Primary: sequencing of amino acids into polypeptide
Secondary: folding or coiling of alpha helix or beta pleated sheets – Hydrogen bonds
Tertiary: final 3D shape of polypeptide – R group interactions
Quaternary: several protein structures come together
...
Direction = NCC with C double bonded to O
furthest away
...
Protein activation
Effected by:
- Sequence of amino acids (mutations),
- The chemical conditions (pH, temperature, salts),
- Binding
o Co-factor: all non-amino acids eg
...
Spindle, flagella anchor proteins
- Storage: albumin (egg whites) for chicken embryo
- Transport: Haemoglobin, importins, Chaperones
- Toxin: Scorpion toxin
- Communication: Ligands (when proteins, can also be lipids, carbs, gases)
- Movement: motor proteins, Dynein heads, Myosin heads
- Enzymatic: -ase, sucrose, DNA polymerase, RNA polymerase, topoisomerase,
helicase
-
Enzymes
Substrate binds to active site on enzyme where it is converted into a product, which is
released to be absorbed
Title: Detailed protein notes
Description: Detailed protein study notes used for first year bachelor of Biomedical science at Queensland University of Technology. Basic foundation for anyone studying or wanting to study biology or medicine at university.
Description: Detailed protein study notes used for first year bachelor of Biomedical science at Queensland University of Technology. Basic foundation for anyone studying or wanting to study biology or medicine at university.