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Title: Sex horemone and Drug
Description: I summery about sex hormone such Estrogen , Progesterone, Testosterone and it’s derivative drug (with its use, finction, cuation, etc) in a simple pattern of Mindmap. It dose help me in review before exam. Hope you like it

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ovulation

-ve feedback

Endometrial gland atrophy

As contraceptive

more viscous Cervical mucus
Impaired glucose tolerance

Hyperglycemia

Effect
Selective of AI : SIAR

HDL

Dyslipidemia

LDL

endometrial CA risk

DUB

Irreversible

Steroid AI

Habitual abortion

risk endomet CA, DVT

Usage

Letrozole

Combine E @HRT for PMS

Aromatase

Dysmenorrhea

aromatase Inhibitor : AI

Anastrozole

Non steroid AI

Reversible

Inactive orally

Reach steady state plasma level in 2-6 weeks

Micronized table for oral

Natural

Fat

IM, topical @vagina
Androgenic

Muscle

@extra-adrenal tissue

SE

Skin

MPA tablet

Breast cell including CA cell

DMPA (depot) IM

Synthesis

17- OH-prohesterone

synthesis @gonadotropin

CPA : Cyproterone acetate

Potent antiandrogenic

Progesterone

Norethisterone

HDL-c

2nd gen

Levonorgestrel
Gestodene

Effect

Hormone response
Endometrial hyperplasia

atherosclerosis

Impaired glucose tolerance

19- Nortestosterone

Hyperglycemia

Factor II, VII, IX, X, XII

3rd gen

Desogestrel

Reg Transcription

Bone mineral density
Synthetic

Norgestimate

Renin

Ampicillin

Antiandrogenic

Drospirenone

Tetracycline

drug intereaction

Tablet
Sodium pregnanediol-20-gluroonide

elimination of TCA

Metabolite

Pill

Gemeprost

❌☹

🚺‼ 1 💊

⬆⬆

Hormone replacement therapy
⚔ 💊
💊
💊

☹ ☹☹

Misoprostol

NSAID induced PU

T+ 5a-reductase
KS :ketosteroid

Assess testis function

Topical, Transdermna

T
...
xxxx : esterification

Fluoxymestrone
Block GnRH LH Surge

Atrophic vaginitis
⚠➕




🚫❌



Severe vasomotor symptome

IM, SC

Dysfunctional uterine bleeding

Synthesis

Ester

Stimulate growth @proper dose

Estriol

1' hypogonadism

Natural form

Replacement

Hypogonadism

Vaginal cream

💊 Postmenopausal syndrome➕
🚫
)❌

Sex hormone and drug

From DHEA , Androstenedione

Estrogel, estroderm

Topical route
Natural

PGE2 analogue
☹)💊
🚺

Micronized tablet

Anti progesterone drug

Intervaginal
💊

Rifampin

tobacco = thrombosis (as long exposure to estrogen

PGE
48 hr after Mifrpristone

Phenytoin

by enzyme inducer

Mifepristone

Competitive inhibitor

Amoxicillin

by antibiotic

Analogue of spironolactone

termination of pragnancy

HTN

anticoagulant

More specific to pregesterone

Assess function of corpus luteum

normal flora
@enterohepatic cir

Thrombosis

Salt, water retention

Less CHO,androgenic, lipoprotein effect

Anti-mineralocorticoid

normal flora

Urine

Endometrium proliferative phase

More androgenic than

1st gen

Enterogepatic cir

G-protein coupling Intracellular receptor

Mech of action

acne

Bile

Secrete

Oral contraceptive

☹ 💊☹ 5


⬇ 🚺
🚹
💊

Estrogen @ ovary

Precursor = Pregnenolone

Compete inhibit T & DHT

K

Activate GnRH

premenopausal

Weak progesterational

Might

For Breast CA + postmenopausal + ER/HER +ve

Exemestane

Endometriosis

prostate gland

Aminoglutethimide

Non selective inhibitor of AI : NSIAR

Thermogenic +0
Title: Sex horemone and Drug
Description: I summery about sex hormone such Estrogen , Progesterone, Testosterone and it’s derivative drug (with its use, finction, cuation, etc) in a simple pattern of Mindmap. It dose help me in review before exam. Hope you like it