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Title: Sex horemone and Drug
Description: I summery about sex hormone such Estrogen , Progesterone, Testosterone and it’s derivative drug (with its use, finction, cuation, etc) in a simple pattern of Mindmap. It dose help me in review before exam. Hope you like it
Description: I summery about sex hormone such Estrogen , Progesterone, Testosterone and it’s derivative drug (with its use, finction, cuation, etc) in a simple pattern of Mindmap. It dose help me in review before exam. Hope you like it
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ovulation
-ve feedback
Endometrial gland atrophy
As contraceptive
more viscous Cervical mucus
Impaired glucose tolerance
Hyperglycemia
Effect
Selective of AI : SIAR
HDL
Dyslipidemia
LDL
endometrial CA risk
DUB
Irreversible
Steroid AI
Habitual abortion
risk endomet CA, DVT
Usage
Letrozole
Combine E @HRT for PMS
Aromatase
Dysmenorrhea
aromatase Inhibitor : AI
Anastrozole
Non steroid AI
Reversible
Inactive orally
Reach steady state plasma level in 2-6 weeks
Micronized table for oral
Natural
Fat
IM, topical @vagina
Androgenic
Muscle
@extra-adrenal tissue
SE
Skin
MPA tablet
Breast cell including CA cell
DMPA (depot) IM
Synthesis
17- OH-prohesterone
synthesis @gonadotropin
CPA : Cyproterone acetate
Potent antiandrogenic
Progesterone
Norethisterone
HDL-c
2nd gen
Levonorgestrel
Gestodene
Effect
Hormone response
Endometrial hyperplasia
atherosclerosis
Impaired glucose tolerance
19- Nortestosterone
Hyperglycemia
Factor II, VII, IX, X, XII
3rd gen
Desogestrel
Reg Transcription
Bone mineral density
Synthetic
Norgestimate
Renin
Ampicillin
Antiandrogenic
Drospirenone
Tetracycline
drug intereaction
Tablet
Sodium pregnanediol-20-gluroonide
elimination of TCA
Metabolite
Pill
Gemeprost
❌☹
🚺‼ 1 💊
⬆⬆
Hormone replacement therapy
⚔ 💊
💊
💊
☹ ☹☹
Misoprostol
NSAID induced PU
T+ 5a-reductase
KS :ketosteroid
Assess testis function
Topical, Transdermna
T
...
xxxx : esterification
Fluoxymestrone
Block GnRH LH Surge
Atrophic vaginitis
⚠➕
➖
➖
➖
➕
🚫❌
➕
➖
➕
Severe vasomotor symptome
IM, SC
Dysfunctional uterine bleeding
Synthesis
Ester
Stimulate growth @proper dose
Estriol
1' hypogonadism
Natural form
Replacement
Hypogonadism
Vaginal cream
💊 Postmenopausal syndrome➕
🚫
)❌
Sex hormone and drug
From DHEA , Androstenedione
Estrogel, estroderm
Topical route
Natural
PGE2 analogue
☹)💊
🚺
Micronized tablet
Anti progesterone drug
Intervaginal
💊
Rifampin
tobacco = thrombosis (as long exposure to estrogen
PGE
48 hr after Mifrpristone
Phenytoin
by enzyme inducer
Mifepristone
Competitive inhibitor
Amoxicillin
by antibiotic
Analogue of spironolactone
termination of pragnancy
HTN
anticoagulant
More specific to pregesterone
Assess function of corpus luteum
normal flora
@enterohepatic cir
Thrombosis
Salt, water retention
Less CHO,androgenic, lipoprotein effect
Anti-mineralocorticoid
normal flora
Urine
Endometrium proliferative phase
More androgenic than
1st gen
Enterogepatic cir
G-protein coupling Intracellular receptor
Mech of action
acne
Bile
Secrete
Oral contraceptive
☹ 💊☹ 5
⬇
⬆
⬇ 🚺
🚹
💊
Estrogen @ ovary
Precursor = Pregnenolone
Compete inhibit T & DHT
K
Activate GnRH
premenopausal
Weak progesterational
Might
For Breast CA + postmenopausal + ER/HER +ve
Exemestane
Endometriosis
prostate gland
Aminoglutethimide
Non selective inhibitor of AI : NSIAR
Thermogenic +0
Title: Sex horemone and Drug
Description: I summery about sex hormone such Estrogen , Progesterone, Testosterone and it’s derivative drug (with its use, finction, cuation, etc) in a simple pattern of Mindmap. It dose help me in review before exam. Hope you like it
Description: I summery about sex hormone such Estrogen , Progesterone, Testosterone and it’s derivative drug (with its use, finction, cuation, etc) in a simple pattern of Mindmap. It dose help me in review before exam. Hope you like it