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10/08/15
Professor Macklin
Biology II
Week 4 extra credit paper
Both humans and animals run on a 24-hour clock that is part day and part night
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The circadian clock, which is a group
of genes, controls this inclination (the circadian rhythms)
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Some obese also have sleep apnea and this lack of sleep messes up their circadian
rhythm
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Knowing that obesity affects one’s sleeping and eating patterns, researchers wanted to
find it if it also affected the vascular system
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The three types of mice were lean, obese, and diabetic
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Then they evaluated the gene expression in the
cardiovascular genes during these three intervals
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However, obese animals did not have a circadian rhythm
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So they looked at specific
molecules from the cardiovascular clock genes and measured their acceleration in blood vessels
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m
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m
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However, in the obese animals this gene stayed the
same throughout the whole day
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This is significant because it helps get the point across to people that obesity is a real
problem that can have damaging effects on people
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This work is very important because now scientists know some of the
defects that obesity gives to the body and now they can come up with ways to help obese people
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And this research helps obese people know what it means to be obese from a health related
standpoint