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Title: Beta agonists in respiratory pharmacology
Description: High yield one page notes on Beta agonists uses in respiratory pharmacology.
Description: High yield one page notes on Beta agonists uses in respiratory pharmacology.
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BETA AGONISTS IN RESPIRATORY PHARMACOLOGY :
Mechanism of action:
Beta agonists work by binding and activating β adrenergic receptors
...
At the cellular level, agonism of β2receptors causes activation of the Gs protein coupled receptor
...
Uses:
Short
acting β2 agonists are used to treat acute bronchospasm
...
They are used
as a prophylactic treatment for asthma, generally in combination with an inhaled glucocorticoids
...
Inappropriate use
of beta agonists as monotherapy causes down regulation of β2 receptors in the airway
...
c
Clinical correlate: Improperly or ineffectively educated patients that use short acting abortive inhalers
(albuterol) too frequently can present to the emergency room because of this exact phenomenon
...
Non-specific β agonist
A non-specific β agonist such as isoproterenol acts by binding and activating both β1 and β2 receptors
...
In addition,
the non-specific activity of isoproterenol can cause significant tachycardia(cardiac β1 stimulation)
Title: Beta agonists in respiratory pharmacology
Description: High yield one page notes on Beta agonists uses in respiratory pharmacology.
Description: High yield one page notes on Beta agonists uses in respiratory pharmacology.