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EPITHELIAL TISSUES
College of Medical Laboratory Science

TOPIC OUTLINE
4
...
Diversity

4 Major types of tissue
1
...
Connective
3
...
Nervous

Cells in epithelia each have:
A
...
basal side (specialized for exocytosis) facing
a basement membrane and underlying
connective tissue
...

Principal functions of epithelial tissue:
1
...

3
...


Covering, lining and protecting surfaces (ex
...
intestines)
Secretion (ex
...
myoepithelial cells)

EPITHELIAL TISSUE

Characteristics:
1
...
Anchoring junctions/ (zonula adherens)
– Chains that mechanically binds adjacent epithelial cells
– site of adhesion
– Provides firm adhesion of one cell to its neighbours so that
they can function as a cohesive unit
...


EPITHELIAL TISSUE
b
...
BBB

INTERCELLULAR JUNCTIONS
• Tight or occluding junctions linear
arrangements of linked proteins surround the
apical ends of the cells and prevent
paracellular passage of substances

EPITHELIAL TISSUE
c
...
5 nm)
– More commonly found in embryo and low density tissues

INTERCELLULAR JUNCTIONS
• Gap or communicating
junctions are points of
cell contact where both
plasma membranes have
numerous
hexameric
complexes
of
transmembrane
connexons,

EPITHELIAL TISSUE
2
...
Basement membrane/ Basal lamina
– Semi solid structure that allows the diffusion of
materials from the underlying connective
tissue
...


BASEMENT MEMBRANE
• Thin
extracellular
layer of specialized
proteins,
usually
having two parts: a
basal lamina and a
more
fibrous
reticular lamina
...

• Reticular lamina contains type III collagen
and anchoring fibrils of VII collagen

EPITHELIAL TISSUE
4
...


Metaplasia
–
–
–
–

Adaptive transformation
A normal tissue is replaced by another normal tissue
...
Non-keratinized squamous epithelium replaces ciliated
columnar cells in the bronchi of smokers

Anaplasia
–
–

Normal to abnormal tissue
Malignant transfor

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