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Title: Eukaryoric Replication
Description: Essay on the mechanism of DNA replication in eukaryotic organisms.
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EUKARYOTIC REPLICATION
Replication starts with helicase unwinding DNA forming a replication fork, while
single-stranded DNA-binding proteins hold each strand to stabilize them, and topoisomerase
prevents the DNA ahead of the fork from coiling
...
DNA polymerase then binds at the site of
primers, and starts synthesizing in a 5’ to 3’ direction
...
The lagging strand synthesis is discontinuous
because its 5’ to 3’ is away from the fork
...
After
synthesis, polymerases remove primers from their respective strands and replace them with
DNA, filling the gaps between fragments
...
Additionally, Pol β repairs nuclear DNA, and
Pol γ is responsible for mitochondrial DNA replication
Title: Eukaryoric Replication
Description: Essay on the mechanism of DNA replication in eukaryotic organisms.
Buy These NotesPreview