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Title: Genetic Interactions Among Viruses
Description: -Genetic mutation/ process/ evolution of viruses - Genome segment of the viruses -Reactivation of the viruses -Complementation and Suppression of Viruses
Description: -Genetic mutation/ process/ evolution of viruses - Genome segment of the viruses -Reactivation of the viruses -Complementation and Suppression of Viruses
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GENETIC INTERACTIONS
AMONG VIRUSES
>>>UNDER CONDITIONS OF
MULTIPLE INFECTION
...
Recombination
>>> IF THE TWO PARENTS ARE
SINGLE- STEPMUTANTS OF
SOME WILD –TYPE STRAIN,
SOME OF THE RECOMBINANTS
WILL HAVE THE WILD-TYPE
GENOTYPE AND PHENOTYPE
>>> VIRUSES MUST BE REASONABLY
CLOSELY RELATED FOR
RECOMBINATION TO OCCUR…
>>> ONLY VIRUSES WITH THE SAME
GENUS RECOMBINE
2
...
H1N1
2
...
H3N2
4
...
MULTIPLICITY REACTIVATION
>>>VIRUSES THAT CONTAIN
DOUBLE- STRANDED DNA
FREQUENTLY EXHIBIT MULTIPLICITY
REACTIVATION AFTER BEING
SUBJECTED TO UV RADIATION…
>>>MULTIPLICITY REACTIVATION IS
RECOGNIZED BY THE FACT THAT THE
FREQUENCY OF VIRAL SURVIVORS
INCREAES SHARPLY WITH
MULTIPLICITIES OF INFECTION…
4
...
PHENOTYPIC MIXING AND
PHENOTYPIC MASKING
>>>REPRESENT A SPECIAL CASE OF
COMPLEMENTATION
>>>WHEN TWO CLOSELY RELATED
VIRUES INFECT THE SAME CELL, THE
TWO TYPES OF PROGENY GENOMES
MAY BECOME ENCAPSIDATED NOT
ONLY BY THEIR OWN CAPSIDS BUT
ALSO BY HYBRID CAPSIDS…
>>>A SIMILAR PHENOMENON
OCCURS AMONG ENVELOPED
VIRUSES, BUT IT ALSO INVOLVES
NOT ONLY VIRUSES THAT ARE
RELATED BUT ALSO VIRUSES THAT
ARE COMPLETELY UNRELATED…
6
Title: Genetic Interactions Among Viruses
Description: -Genetic mutation/ process/ evolution of viruses - Genome segment of the viruses -Reactivation of the viruses -Complementation and Suppression of Viruses
Description: -Genetic mutation/ process/ evolution of viruses - Genome segment of the viruses -Reactivation of the viruses -Complementation and Suppression of Viruses