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Title: Transes for Hematology 1_ Chapter 1
Description: This is a summary of each chapter. this included notes, pictures and recall questions at the end of each chapter. Hope this helps in studying. *Note that chapters will be uploaded orderly
Description: This is a summary of each chapter. this included notes, pictures and recall questions at the end of each chapter. Hope this helps in studying. *Note that chapters will be uploaded orderly
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HEMATOLOGY
HEMATOLOGY Lecture
CHAPTER 1:
A
...
• Study of hemostatic mechanisms, hemorrhagic disease
and thrombosis
Hemostasis
•
“Process of stopping bleeding by interaction of:
o Platelets
o Blood vessels
o Proteins
Blood
- Nutritive fluid circulating the body, carrying
nutrients, oxygen, and waste product
...
MEDICINE”
-
4 elements made up the human body
Aristotle
▪
Concept of “cooking” or “concoction” in
the stomach
Erasistratus
- “Plethora”
▪ Excess blood due to presence of
undigested food, thus bleeding the
patient is the solution to this
...
▪ 1st to distinguished polymorphonuclear cells
▪ Use Aniline dye
HISTORY
▪
RENAISSANCE PERIOD
▪ Accurately described platelets
➢ 1879--- Ehrlich
▪ 1st complete classification of WBC
➢ 1882--- Giulio Bizzozero
▪ Describes platelet morphology and
function
➢ 1891--- Romanowsky
▪ Mixtures of acidic and basic dyes have better
stain
➢ 1816-1895--- Virchow
▪ “FATHER OF MODERN PATHOLOGY”
▪ Studied cell function
▪ 2 students:
o Karl Ludwig-- hemoglobin carries
oxygen
E
...
Pfluger-- CO2 taken away to tissue and
o
released in lungs
▪
Aulus Cornelius Celsus
▪ Four signs of inflammation
▪ Importance of anatomy
20TH CENTURY
➢ 1962 --- Max Perutz & John Kendrew
▪ Discover structure and function of
hemoglobin
...
D
...
Respiration
2
...
Excretion
4
...
Maintenance of pH and temperature
6
...
Protection
Function: Stop bleeding
Life span: 10 days in blood stream
Production site: Megakaryocytes
*Not whole cells but fragments of
cytoplasm of Megakaryocytes
...
35-7
...
045-1
...
)
Eosinophil
Plasma contains:
➢
➢
➢
➢
➢
Water (>90%)
Proteins
Carbohydrates
Vitamins
Hormones
RATIO:
WBC
1
➢ Lipids
➢ Salts, Minerals,
Electrolytes
➢ Non protein nitrogen
➢ Enzymes
Basophil
E
...
HEMATOLOGICAL DISEASES
➢ Primary / Inherited
➢ Secondary/ Acquired
➢ Due to:
o Improper production of cell type
▪ Leukemia--- ↑ WBC count, ↓ function
▪ Anemia ---- ↓RBC count
▪ Thrombocytopenia− ↓ 𝑝𝑙𝑎𝑡𝑒𝑙𝑒𝑡 𝑐𝑜𝑢𝑛𝑡
o
o
Increase loss
Defective cell function (WBC & Plt
...
▪ RATIO
▪ Plasma: Total blood vol
...
2
...
4
...
6
...
▪ Heart – Lungs—Heart
Systemic circulation
Plasma Volume
8
...
10
...
12
...
14
...
16
...
Explain this condition and their
solution
...
Pregnancy
c
...
Polycythemia
d
...
Which of the following dye is not used in measuring
Plasma volume?
a
...
Evans blue
b
...
I131
18
...
Cr51
c
...
𝑷
d
...
What blood vessel structure is lined by glycocalyx?
20
...
What blood vessel can carry both oxygenated and
deoxygenated blood?
22
...
The protective function of blood is the main purpose of?
24
...
What interacts in the blood in hemostasis process?
3
Title: Transes for Hematology 1_ Chapter 1
Description: This is a summary of each chapter. this included notes, pictures and recall questions at the end of each chapter. Hope this helps in studying. *Note that chapters will be uploaded orderly
Description: This is a summary of each chapter. this included notes, pictures and recall questions at the end of each chapter. Hope this helps in studying. *Note that chapters will be uploaded orderly