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Title: Edexcel as level biology question paper 1 june 2024 salters Nuffield + mark scheme
Description: Mark Scheme (Results) Summer 2024 Pearson Edexcel AS Level GCE In Biology A Salters Nuffield (8BN0) Paper 01: Lifestyle, Transport, Genes and Health

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Edexcel as level biology
question paper 1 june
2024 salters Nuffield +
mark scheme

Please check the examination details below before entering your candidate information
Candidate surname

Centre Number

Other names

Candidate Number

Pearson Edexcel Level 3 GCE

Monday 13 May 2024
Morning (Time: 1 hour 30 minutes)

Paper
reference

8BN0/01

Biology A (Salters Nuffield)

 

Advanced Subsidiary
PAPER 1: Lifestyle, Transport, Genes and Health
You must have:
Scientific calculator, HB pencil, ruler

Total Marks

Instructions

Use black ink or ball-point pen
...

Answer all questions
...


the questions in the spaces provided
• Answer
– there may be more space than you need
...


marks for each question are shown in brackets
• The
– use this as a guide as to how much time to spend on each question
...


Advice

Read each question carefully before you start to answer it
...


• Check your answers if you have time at the end
...

F:1/1/1/1/1/1/1/

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1 The diagram shows part of the internal structure of a human heart
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(1)

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Some questions must be answered with a cross in a box
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Answer ALL questions
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(iii) Describe the role of this semilunar valve in the cardiac cycle
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(b) The diagrams show a cross-section of an aorta and a vena cava
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(ii) Which of the following would be in contact with the blood in an undamaged
vena cava?

(1)

(1)

A
collagen
B
endothelial cells
C
epithelial cells
D
smooth muscle cells
(Total for Question 1 = 7 marks)

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3

Turn over

Plants with genotype FRFR have flowers with red petals
...


white flowers
  pink flowers

red flowers
(Source: © Irina Kryvasheina/Alamy Stock Photo)



(a) Deduce why heterozygous snapdragon plants produce flowers with pink petals
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4

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2 The photograph shows red, white and pink snapdragon flowers
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Determine the probability of each petal colour in the offspring of this cross,
using a genetic diagram
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Predict how many of these plants will have flowers with white petals
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(Total for Question 2 = 7 marks)

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5

Turn over

(a) The diagram shows the structure of a nucleotide
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Name structure R in a DNA nucleotide and in an mRNA nucleotide
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mRNA nucleotide 
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(b) The diagram shows a polypeptide chain
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(iii) Describe the role of RNA in the formation of this polypeptide chain
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Glucose molecules can also enter red blood cells
...

Molecule

Properties

Glucose

large, polar molecule

Oxygen

small, non-polar molecule

Describe how oxygen and glucose molecules can enter red blood cells
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(b) Collagen and haemoglobin are proteins associated with the
cardiovascular system
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(3)


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The effect of concentration of three different alcohols on the haemolysis of
red blood cells was investigated
...

The table shows the formulae of the alcohols
...

The investigation was repeated twice
...

100

butanol

75
Percentage of
red blood cells
50
haemolysed (%)

25

propanol
ethanol

0
0
...
25
0
...
75
1
...
25

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(i) State and justify a suitable control for this investigation
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(4)


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(Total for Question 4 = 11 marks)

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*P74472A01332*

13

Turn over

(a) (i) Describe the function of DNA polymerase in producing a polynucleotide
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Discuss the possible benefits of this property of DNA polymerase
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(b) Some people have DNA polymerase that cannot detect and correct errors in
DNA replication
...

The increased risk of cancer occurs when a person inherits two faulty recessive
alleles of the DNA polymerase gene
...

Key
A

male without cancer

B

male with cancer
female without cancer
female with cancer
Individuals A and B wish to have another child
...


(2)


...



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(a) Which of the following statements about polysaccharides is correct?

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(1)

A
starch contains amylose, a straight chain containing 1,6 glycosidic bonds
B glycogen contains amylopectin, a branched chain containing both
1,4 and 1,6 glycosidic bonds
C polysaccharides containing both 1,4 and 1,6 glycosidic bonds allow a
rapid release of energy
D
starch and glycogen are both soluble in water

16

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6 The effect of enzyme concentration on the rate of reaction was investigated
...


increasing concentration of starch present
no starch

high starch concentration

yellow-brown colour

blue-black colour

The effect of amylase concentration on the rate of reaction, at two different
temperatures, was investigated
...


18

Enzyme concentration
/ mmol dm–3

Rate of reaction at 30 °C
/ a
...


Rate of reaction at 45 °C
/ a
...


0

  0

 0

1

 31

16

2

 41

25

3

 69

36

4

 82

42

5

 92

47

6

 98

54

7

100

62

8

100

70

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The diagram shows the effect of adding iodine to flasks containing different
concentrations of starch
...


(6)


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19

Turn over

(ii) Comment on the effects of enzyme concentration and temperature in
this investigation
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(a) The table shows categories of BMI
...
9

normal

25–29
...

He has a normal BMI
...

Use the formula
BMI =

mass
(height in m)2
(2)

minimum height
...
m



*P74472A02132*

21

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(b) One risk factor for coronary heart disease (CHD) is obesity
...


(2)


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(ii) State one risk factor for CHD other than obesity
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(c) The table shows the number of deaths due to CHD in three countries
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(4)

23

Turn over

(d) Atherosclerosis is a type of cardiovascular disease (CVD) that causes the
narrowing of coronary arteries
...

Balloon angioplasty can reduce the immediate risk of a person having a
heart attack
...


guiding catheter

narrowed coronary artery

balloon catheter with
uninflated balloon

balloon catheter with
inflated balloon
unblocked coronary
       artery

24

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(ii) Explain why balloon angioplasty could reduce the immediate risk of a person
having a heart attack
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(2)

Answer
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(2)


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26

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The photograph shows the nematode Caenorhabditis elegans, as seen using an
electron microscope
...


(b) Humans have a circulatory system
...

120

Mean arterial pressure

100
80
Blood pressure
60
/ mm Hg
40
20



Venae cavae

Medium and large veins

    

Venules

Capillaries

Arterioles

Arteries

0
Aorta

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(i) Explain why the blood pressure increases and decreases in the aorta
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Give your answer to two significant figures
...
%

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*P74472A02732*

27

Turn over

(c) The squid is an invertebrate animal that lives in the sea
...

The gills contain gas exchange surfaces
...


(3)


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(ii) A student wished to investigate the effect of caffeine on the heart rate of
some vertebrate and invertebrate organisms
...


(2)


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...
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Summer 2024
Question Paper Log Number P74472A
Publications Code 8BN0_01_2406_MS
All the material in this publication is copyright
© Pearson Education Ltd 2024

General Marking Guidance



All candidates must receive the same treatment
...




Mark schemes should be applied positively
...




Examiners should mark according to the mark scheme not according to their
perception of where the grade boundaries may lie
...
All marks on the mark scheme should be
used appropriately
...
Examiners
should always award full marks if deserved, i
...
if the answer matches the
mark scheme
...




Where some judgement is required, mark schemes will provide the principles
by which marks will be awarded and exemplification may be limited
...




Crossed out work should be marked UNLESS the candidate has replaced it
with an alternative response
...
5 / 50% / ½}
{0
...
25 / 25% / ¼}

Additional Guidance

(3)

Mark

Example of calculation:
0
...


(4)

Question
Number
4(a)

Answer

Additional Guidance

Mark

A description that makes reference to the following:


(oxygen) diffuses {from an area of high concentration to an
area of low concentration / down the concentration gradient}
(1)



(glucose) enters the cell {through carrier proteins / by
facilitated diffusion} (1)

ALLOW oxygen enters cell by
(simple) diffusion
ALLOW enters cell by active
transport (against concentration
gradient)
ignore channel proteins

(2)

Question
Number
4(b)

Answer

Additional Guidance

Mark

An answer that makes reference to three of the following:


collagen is a fibrous protein whereas haemoglobin is a
globular protein (1)

collagen is {long chain/ linear}
whereas haemoglobin is {spherical
/compact}



collagen is composed of three polypeptide (chains)
whereas haemoglobin is composed of four polypeptide
(chains) (1)

ALLOW repeating sequences of
amino acids in collagen and not in
haemoglobin



collagen has (little to no) tertiary structure whereas
haemoglobin has a quaternary structure (1)

ALLOW haemoglobin has
{disulphide bridges / ionic bonds /
quaternary structure} whereas
collagen does not



haemoglobin has {prosthetic group / haem group / iron
(ion) / α-helix / β-pleated sheet} whereas collagen does
not (1)

ALLOW haemoglobin is conjugated



hydrophilic (R) groups on (surface of) haemoglobin and
hydrophobic (R) groups on (surface of) collagen (1)

(3)

Question
Number
4(c)(i)

Answer

Additional Guidance

Mark

An answer that makes reference to the following:


saline / solution with no alcohol / 0
...
g
...

The indicative content below is not prescriptive and candidates are not required to include all the material
which is indicated as relevant
...

Basic





use of range of enzyme concentrations
use of given range i
...
0-8 mmol dm-3
reference to both given temperatures – 30°C and 45°C
relevant safety aspect

Linkages
• variables controlled e
...
, volume of {amylase/starch/iodine} solution, concentration of starch solution,
pH, temperature, time
• explanation of how a stated variable would be controlled e
...
use of water bath to maintain temperature
/ stated volume of solution
• replicates / repeats
Sustained
• method to measure rate of reaction e
...
, time taken for iodine solution to remain yellow-brown / use of
colour standards for comparison / reference to use of regular sampling to test with the indicator /
reference to use of colorimeter

description of how to calculate rate of reaction e
...
calculate gradient, 1/t

(6)

Level 1

1-2

Level 2

3-4

Level 3

5-6

Additional Guidance
An explanation of how the investigation should be
A basic method described with reference to
modified may be attempted but with limited analysis,
range of enzyme concentrations and use of
interpretation and/or evaluation of the scientific
starch and iodine solutions
...
Generalised comments made
...

• variables to be controlled
• how to control at least one variable
• how to measure rate of reaction
• how to calculate rate of reaction
An explanation of how the investigation should be
Level 1 plus
modified will be given with occasional evidence of
Consideration of two more of the following:
analysis, interpretation and/or evaluation of the
• performed at both temperatures – 30°C
scientific information
...

• how to measure rate of reaction
• how to calculate rate of reaction
An explanation of how the investigation should be
A detailed method for a valid investigation which
modified is given which is supported throughout by
also includes how to calculate rate of reaction
evidence from the analysis, interpretation and/or
from the dependent variable data
evaluation of the scientific information
...


Question
Number
6(b)(ii)

Answer

Additional Guidance

Mark

An answer which makes reference to four of the following:


the rate of reaction increases as concentration
increases (1)

ALLOW piece together



enzymes had a higher rate of reaction at 30°C (than at
45°C) (1)

ALLOW converse



the rate of reaction is lower at 45°C (than 30°C)
because {it is above the optimum temperature for
amylase / (some of) the enzyme has denatured} (1)

ALLOW optimum temperature closer
to 30°C than 40°C
ALLOW the active site of the enzyme
has {been affected / changed
shape} at the higher temperature



{at higher enzyme concentration / 30°C} more
enzyme-substrate complexes form (1)

ALLOW {at lower enzyme
concentration / 45°C} fewer
enzyme-substrate complexes form



at 30°C the rate of reaction plateaus (at 100 a
...
/ 7
mmol dm-3) due to a named limiting factor (1)

e
...
substrate concentration
(4)

Question
Number

Answer

7(a)



(minimum height) {1
...
616 / 1
...
8 / 1
...
g
...
2 to 10
...
g
...
8(%)
no ecf
Correct answer with no working gains full
marks

(2)

Question
Number
8(c)(i)

Answer
An answer which makes reference to three of the following:

Additional Guidance

Mark

Full marks can only be awarded if
answer contains both similarities and
differences
...
g
...
Registered company number 872828
with its registered office at Edinburgh Gate, Harlow, Essex CM20 2JE


Title: Edexcel as level biology question paper 1 june 2024 salters Nuffield + mark scheme
Description: Mark Scheme (Results) Summer 2024 Pearson Edexcel AS Level GCE In Biology A Salters Nuffield (8BN0) Paper 01: Lifestyle, Transport, Genes and Health