Search for notes by fellow students, in your own course and all over the country.
Browse our notes for titles which look like what you need, you can preview any of the notes via a sample of the contents. After you're happy these are the notes you're after simply pop them into your shopping cart.
My Basket
multiple myeloma£3.13
DSA£0.50
Psychology and Sociology Intro/ MCAT£50.00
Photosynthesis £2.50
Cell Lysis Techniques£6.25
Gender and Ageing Notes£13.69
Respiration £0.70
Transes for Hematology 1_ Chapter 1£2.00
Wildlife Management - Population Growth and Regulation£5.00
Classification of Organisms£5.00
Important Organelles and Functions£0.90
Notes on Biological Classification£2.00
Morphogenesis£12.50
Lecture 2 -Physical controls on the distribution of organisms £0.76
TWINS ARTICLE£3.75
Biological Explanation of Depression A02 16 marks£12.50
GCSE Edexcel Additional Biology£2.50
GCSE Physics 2.6 - The Universe£0.89
DNA Replication, Mutation and Repair£1.50
Biochemistry Lecture 1 full notes£4.38
Cilia and Flagella £1.75
Exchange and transport essay£8.75
Fundamental unit of life£0.50
3P EXAM STUDY APEA COMPREHENSIVE AND ACTUAL CORRECT ANSWERS£15.84
Kentone Metabolism£0.54
Continuous and discontinuous variations£1.00
GCSE biology notes£2.50
Diversity class 9 £0.50
AQA AS BIOLOGY BLOOD VESSELS£1.50
Fameous Scientist£2.50
Essay guidelines£3.75
Bio 101 Chapter One Outline Science Theory£1.50
Reflex Actions - GCSE Core Study£2.50
Fundamental of nutrition£0.50
OCR 2024 GCSE Biology B (Twenty First Century Science) J257/03 Breadth in biology (Higher Tier) With Marking Scheme Merged£5.00
Mutualistic relationships£1.50
Maxillomandibular jaw relation £4.50
Biopsychosocial Model of Clinical Depression£5.00
Disorders part-2£18.74
Biology Exam Review£10.00
FETUS ARTICLE£3.75
Ch. 10 Fundamental Cellular Processes III: Bio 1500 Notes £2.00
Tutorial (Accuracy, Precision and Errors) with answer£2.50
business£12.50
Microbial Growth£2.50
General knowledge Quiz £13.13
Best of Cardiovascular system for medical student£2.50
Evolutionary biology of animals£6.25
Effects of smoking £12.50
Immunology notes part 1£6.25
Nucleic Acids and Inorganic Ions£3.75
1. Cell Biology£2.50
Sexual reproduction in flowering plants part 1 NCERT class 12th Biology Neet£13.75
Introduction to Microbials£3.75
Total£306.43
Document Preview
Extracts from the notes are below, to see the PDF you'll receive please use the links above
Introduction to
Protein Structure Prediction
BMI/CS 776
www
...
wisc
...
wisc
...
, 1950s]
• but some qualifications
– all proteins can be denatured
– some proteins are inherently disordered (i
...
lack a
regular structure)
– some proteins get folding help from chaperones
– there are various mechanisms through which the
conformation of a protein can be changed in vivo
– post-translational modifications such as
phosphorylation
– prions
– etc
...
g
...
g
...
Rost, “Protein Structure in 1D, 2D, and 3D”, The Encyclopaedia of Computational Chemistry, 1998
Prediction in 3D
• homology modeling
given: a query sequence Q, a database of protein structures
do:
• find protein P such that
– structure of P is known
– P has high sequence similarity to Q
• return P’s structure as an approximation to Q’s
structure
• fold recognition (threading)
given: a query sequence Q, a database of known folds
do:
• find fold F such that Q can be aligned with F in a highly
compatible manner
• return F as an approximation to Q’s structure
Prediction in 3D
• “fragment assembly” (Rosetta)
given: a query sequence Q, a database of structure
fragments
do:
• find a set of fragments that Q can be aligned with in a
highly compatible manner
• return fragment assembly as an approximation to Q’s
structure
• molecular dynamics
given: a query sequence Q
do: use laws of Physics to simulate folding of Q
Prediction in 3D
homology
modeling
threading
fragment assembly
(Rosetta)
molecular
dynamics