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Title: Haemostasis
Description: Diagrammatic representation of the physiology of blood clotting and coagulation. Simple and concise, aimed at early medical and physiology students
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Haemostasis:
• Arrests bleeding
• initiates repair of blood vessels
• Maintains vascular integrity - after wear and tear

Coagulation
intrinsic pathway (in vitro):
negative charge

extrinsic pathway:
III (tissue factor)

XII

Myogenic

XI
IX VIII
Ca2+

Ca2+

VII

X

end

monocytes
phospholipid

2
o
xA ser
T

I (fibrin)

PDGF

Plasmin
Plasminogen
t-PA

Platelet activation
• adhesion
• activation - Ca2+ influx
• aggregation (platelet plug
formation)
- blocks small
holes
- fibrin prevents
break down

collagen

pro
t
rec hromb
ept
or in

fibrinogen

Fibrinolysis

Eg: precapillary sphincter

TxA2
ADP

II (thrombin)
Ca2+

• proteolysis
• polymerization
• cross-linking

to

Inflammation?
cytokines?

n
ni

Aspirin

Ca2+ V

prothrombin

oth

Vasoconstriction Neurogenic
Pain?
elin

FDPs
(fibrinogen
degradation
products)

fibroblasts

activated
endothelium

Loose CT

Smooth
muscle

3
...
Spontaneous bleeding into muscles and joints
• Liver disease - liver produces coagulation factors
• Vitamin K deficiency - fat malabsorption, or oral antibiotics can kill bacteria in the gut that
produce vitamin K
Title: Haemostasis
Description: Diagrammatic representation of the physiology of blood clotting and coagulation. Simple and concise, aimed at early medical and physiology students
Buy These NotesPreview