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Title: Anti-asthmatic Drugs (Drug Study)
Description: Overview of different kind of anti-asthmatic drugs.
Description: Overview of different kind of anti-asthmatic drugs.
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DRUG STUDY
NAME: RIE NICOLE R
...
A
...
A
...
Theophylline competitively
inhibits type III and type IV
phosphodiesterase (PDE),
the enzyme responsible for
breaking down cyclic
AMP in smooth muscle
cells, possibly resulting in
bronchodilation
...
In
inflammatory states,
theophylline activates
histone deacetylase to
prevent transcription of
inflammatory genes that
require the acetylation of
histones for transcription to
begin
...
It
works by relaxing the
muscle around the
airways in the lungs
...
Theophylline has few
outright contraindications
for use other than a history
of hypersensitivity to
theophylline or any inactive
ingredient in the drug
...
Potentially Fatal:
Convulsions, cardiac
arrhythmias,
hypotension and
sudden death after too
rapid IV injection
...
texture, lesions; reflexes,
bilateral grip strength,
A very serious allergic reaction
affect; P, auscultation, BP,
to this drug is rare
...
• Interventions
•
•
•
Caution patient not to
chew or crush entericcoated timed-release
preparations
...
Do not give timed-release
preparations with food;
400 mg/24 hours; 450 mg;
600 mg/24 hours)
•
these should be given on
an empty stomach, 1 hr
before or 2 hr after meals
...
WARNING:
Monitor results of serum
theophylline level determinations
carefully, and reduce dosage if
serum levels exceed therapeutic
range of 10–15 mcg/mL
...
WARNING:
Keep diazepam readily
available to treat seizures
Title: Anti-asthmatic Drugs (Drug Study)
Description: Overview of different kind of anti-asthmatic drugs.
Description: Overview of different kind of anti-asthmatic drugs.