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Title: Antigen
Description: It contains complete description of antigen. Epitope peritope, determinant of antigenicity etc
Description: It contains complete description of antigen. Epitope peritope, determinant of antigenicity etc
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ANTIGEN
Antigen:-These are the substance which when entered inside host produces antibodies with
which they react specifically in an observable manner
...
Immunogen:- substance which stimulates immune response when entered inside body
...
Antigenicity:- The property of eliciting production of Abs and reacting specifically in an
observable manner
...
Attributes if antigen:i
...
ii
...
Types of antigen:i
...
Hapten:-they can react with specific Abs but cannot produce immune
response(Once they combine with larger molecule carrier they are
immunogenic)
...
complex(precipitating)(polyvalent)
ii
...
Epitope are two types:
i
...
Conformational
T cell recognizes linear eiptope while B cell recognize Conformational epitope
...
Some of the LMW antigens non antigenic but if they are absorbed in large molecular
weight substance (like-bentonite and kaolin) they render Antigenicity
...
They are like haptens
...
The Antigenicity depends on diversity of antigens
For ex:- Proteins are more antigenic than polysaccharides as they are made up of 20 aa
while polysaccharides are made up of 4 or 5 monosaccharide’s
...
Susceptible to tissue enzyme: The antigens which are susceptible to tissue enzymes are
antigenic
...
Those
which are not susceptible to enzymatic degradation are not antigenic and even those who do
quickly
...
Foreignness: Antigens which are foreign only induce immune response
...
Antigenic specificity: The ability of host cell to recognize specific antigen
...
(cross reactions occurs depending on
there resemblance of stereochemical nature
...
Species specificity-All individual of a species have species specific antigen
...
There immunological
reaction follows phylogenetic relation
...
Ex- When an individual is sensitized by horse serum it shows
hypersensitivity reaction to other equine serum but not bovine serum
...
Iso specificity-These antigens are present in some but not all individual of
species
...
Ex- human erythrocyte antigen
...
3
...
Ex; Eye lens protein, Sperm
...
Organ specificity-Some of the tissue antigens are present in different
species
Title: Antigen
Description: It contains complete description of antigen. Epitope peritope, determinant of antigenicity etc
Description: It contains complete description of antigen. Epitope peritope, determinant of antigenicity etc