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Brain Kidney And Lens protein
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Heterogenic Specificity;-some of the antigens are present in different species, class,
family kingdoms and phylum
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They are absent in rabbit so they are used to prepare antibodies
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For ex- Weil Felix test (Typhus Fever) PaulBunnel Test (Infectious mononucleosis) cold Agglutination test (atypical Pneumonia)
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T cell dependent(TD)
2
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They need to be mediated by T cell
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This MHCII receptor causes T cell to differentiate into T(h) cells
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It interact with CD40 receptor on B cell to
produce Ab
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They interact
with BCRs of innate immunity
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Type 1- Directly mitogenic and cause polyclonal B cell activation
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Type 2- They activate B cell to generate Abs with help of cytokinines and also activate
complement system
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[These are
usually lipids sugar and nucleic acid]
Superantigens- These are antigenic molecules which when introduced activates massive
number of T cells
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They have high molecular weight
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They don’t bind in the groove between  and  chains of MHCII receptor, they rather
bind lateral to  chain and V chain of TCR
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Determinant recognized by innate immune system:Adaptive immunity they recognize discrete determinants and demonstrate high degree
specificity
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These molecular patterns are pathogen associated molecular patterns
(PAMPs) and receptors are pattern recognition receptors (PRRs)
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Toll like receptors-Trans membrane receptors on macrophages and
dendritic cells
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2
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3
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